Link Between Obesity, Diabetes and Liver May Lead to New Therapies

The links between obesity and type 2 diabetes are well-known, but why they are linked is still not well understood. One reason could be the effect that extra body weight has on liver function, a new study has found. An international team of scientists found that over-expression of a specific protein in the liver, caused by obesity, could be the key.

The protein, called tyrosine phosphatase receptor gamma (PTPR-y) acts as a molecular link between obesity-induced inflammation and insulin resistance. This is specifically associated with type 2 diabetes mellitus (T2DM).

The research team focused on PTPR-y and inflammation of the liver.

The researchers were led by Roberto Coppari, PhD, at the University of Geneva (UNIGE) Facility of Medicine Diabetes Centre and included colleagues from Switzerland, Japan, the United States, and France. Human data from those varied sources were also used to conduct the research.

The findings started with an initial analysis of the human data and how the PTPR-y expression was altered in obese individuals. They found that it does increase with obesity and its resulting liver inflammation, which they theorized could be inhibiting insulin receptors' action. The team then turned to mice.

The team reduced or increased expression of PTPR-y in mice. Slowing it did not prevent mice from becoming obese on a high-calorie diet, but it did lower or stop their insulin resistance. These same mice had a higher glucose tolerance. Their incidence of diabetes symptoms were thus far lower than in control subjects.

“In summary, our results indicate that the increased hepatic PTPR-? level observed in obesity is sufficient to cause insulin resistance and hence unveil PTPR-? as a new target for anti-T2DM therapy,” the authors wrote. “Our data suggest that means aimed at decreasing hepatic PTPR-? expression/activity should improve T2DM. This goal could be achieved by development of specific PTPR-? inhibitors.”

Source: GenengNews.com

More Articles

More than 71 million Americans suffer from high levels of low-density lipoprotein (LDL) cholesterol. High LDL cholesterol increases the buildup of...

A study at the Karolinska Institutet in Sweden shows that type one diabetes can be prevented in mice.

The Study

Using diabetes-...

Diabetic shoes are important as a common side effect of diabetes is "peripheral neuropathy," which causes loss of sensation in the extremities....

In the search for a diabetes cure, a study stunned even the experts involved. Scientists at a Toronto medical center published findings that...

Bilberry tea sounds like the favorite drink at a Hobbit cafe, but the mild sounding bilberry comes with a tall list of powerful health benefits....

More Articles

Keeping your blood sugar levels under control can be tough. There are so many factors that can affect blood sugar, like exercise, food, illness,...

Having diabetes affects your body’s ability to handle hot, humid weather, and steamy temperatures can degrade diabetes supplies. But all of this...

A common complication associated with diabetes is swollen feet. The swelling can...

A mood is an internal state or condition of feeling. It colors everything else we experience, much like colored sunglasses add a tint to...

When diet, exercise, and metformin are not enough to manage type 2 diabetes, physicians might recommend a non-insulin injection medication to help...

Prednisone is a corticosteroid, which means that it is used to treat certain conditions in the body that are caused by low steroid production....

Bilberry tea sounds like the favorite drink at a Hobbit cafe, but the mild sounding bilberry comes with a tall list of powerful health benefits....

Eating LCHF, or a Low Carb High Fat diet, is a bit mind-bending for those of us who have learned to consume low-fat and lean. In many respects, it...

Because beets have moderately high sugar content, it’s typically recommended that people watching their glucose levels limit beet consumption....

In the search for a diabetes cure, a study stunned even the experts involved. Scientists at a Toronto medical center published findings that...

Fluid retention, also known as edema, is a problem that affects many diabetics, especially those with type 2 diabetes...

Individuals with type 1 or type 2 diabetes experience low blood sugar while sleeping more often than they or their doctors may realize, according...

The bodies of those who suffer from type 1 diabetes cannot make insulin on their own. For this reason, patients are subject to multiple injections...

When diagnosed with type 2 diabetes, many people panic and are concerned that their life is over. In fact, if the...

The human body needs chromium, a trace mineral, for several essential functions including the normalizing of...