Australian Researchers Develop Long-lasting Insulin Injections

Research from Australia has found a more effective, longer-term drug for treating type 2 diabetes. The research finds that the new injections reduce side-effects and improve performance for longer-term insulin control in type 2 diabetics. Studies published in the Journal of Medicinal Chemistry and BBA-General Subjection found that the new drugs may be more efficient in blood sugar reduction.

The new drugs work by targeting a protein receptor called PPARgamma, found in fat tissues throughout the body. The drugs lower blood sugar by increasing sensitivity to insulin and changing the metabolism of fat and sugar.

The studies looked at 14 versions of a drug which partially activates PPARgamma and another drug, rivoglitazone, binds with PPARgamma receptors.

The first study examined the fourteen drugs and how they partially activate the PPARgamma receptors and the resulting lower side-effects compared to drugs which fully activate PPARgamma. This could combine with the use of rivoglitazone, the researchers hope, which can bind with PPARgamma receptors and control blood sugar levels.

The combination of these drugs could result in a treatment option that gives a more stable control of insulin and for a much longer duration per injection. That would reduce the number of injections required for the patient and lower the side-effects associated with insulin control injections.

The research is continuing at the University of Adelaide in Australia in collaboration with researchers in the United States and Europe.

Source: TheCable

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