Women With PCOS Have Four Times the Risk of Diabetes

A new study suggests that women with polycystic ovary syndrome (PCOS) are at four times the risk for type 2 diabetes. PCOS is widespread in women of reproductive age and is the leading cause of female infertility. Up to 5 million women in the United States are affected by PCOS. It's been known that women with PCOS have insulin resistance, causing them to over-produce insulin and thus be at higher risk for type 2 diabetes.

The study, conducted in Denmark, was published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism. It was a population-based study looking at the connection between PCOS and type 2 diabetes and aims to fill the research gap there, says lead author Katrine Hass Rubin of the Institute of Clinical Research at the University of Southern Denmark in Odense.

Looking at 19,639 premenopausal women diagnosed with PCOS found the link.

The research looked at the near-20,000 women included and their glucose, testosterone, triglycerides, and cholesterol levels compared to women who were healthy and non-PCOS. The study used three times as many controls as subjects, for a total of 54,680 participants.

After adjusting for other potential risk factors for type 2 diabetes (body mass index, contraceptives use, etc), the study authors found that women with PCOS were four times more likely to be diagnosed with type 2 diabetes. The average age of diagnosis was 31. Women without PCOS who were eventually diagnosed with type 2 diabetes are diagnosed at an average age of 35.

The study found that of the risk factors adjusted for, BMI and glucose levels were most closely related with type 2 diabetes risk with or without PCOS. A higher number of child births seemed to mitigate the risk somewhat, leading the researchers to believe another avenue of research may be possible. The impact of contraceptives on both PCOS And type 2 diabetes was also noted as a potential new avenue of research.

Source: MedicalNewsToday.com

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