New Tool For Accelerated Wound Healing Developed

Effective and inexpensive tools that accelerate wound healing are currently lacking, but researchers recently developed a new approach.

The innovative technology uses lactic acid bacteria to produce and transfer a human chemokine to wound sites. Chemokines are molecules that attract infection-fighting white blood cells.

“We have developed a drug candidate, a next-generation biologic medical product, and are now publishing the fantastic results from the preclinical part where wound healing was strongly accelerated in mice,” said professor Mia Phillipson, Department of Medical Cell Biology, Division of Integrative Physiology, Uppsala University.

The new drug is applied topically to wounds where the chemokine, called CXCL12, favorably changes the behavior of specific immune cells. The lactic acid, besides generating and transferring CXCL12, also lowers the wound area’s pH. This inhibits CXCL12’s degradation, allowing more immune cells to be recruited for healing.

The drug’s powerful acceleration of healing was not only demonstrated in healthy mice, but in diseased ones as well, including some with diabetes.

Technology such as this could transform wound care that is currently limited to debridement, dressings, and extensive antibiotic therapy. Because of our aging population, the increase of chronic diseases such as diabetes, and growing antibiotic resistance new and effective wound therapy could have a substantial impact.

“This is very exciting from a health care perspective. We have a technology that works and now understand the mechanism behind it, how it accelerates wound healing. The next step is a study in a pig model,” said Professor Phillipson.

The research was published in the Proceedings of the National Academy of Sciences.

Source: Alpha Galilieo/Uppsala University
Photo credit: University of Exeter

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