Naturally Occurring Molecule Effective For Diabetes Related Disease

A molecule called Resolvin E1 is manufactured naturally in our body from omega-3 fish oil.

When topically applied to gum tissues Resolvin E1 prevents or treats gum disease, and lowers the likelihood that advanced arterial plaques will rupture to form life-threatening blood clots.

These findings may lead to safe therapies for the prevention and treatment of heart and gum disease. It also heralds a paradigm shift for the care of local and system-wide inflammatory conditions frequently associated with type 2 diabetes, and obesity.

An individual’s risk for cardiovascular disease increases with the onset of diabetes, and inflammation may be a primary factor in heart disease development. Now, there is mounting evidence that inflammatory related conditions such as diabetes, heart disease, and kidney disease may benefit from the effects of lipid mediators, such as Resolvin E1, that form in our cells during the breakdown of polyunsaturated fatty acids, such as omega-3s.

To determine the effectiveness of lipid mediators on heart disease, researchers engaged two groups of an experimental model with severely advanced atherosclerosis (a build up of plaque in the arteries). The first group had a solution containing Resolvin E1 applied to their gum tissues. The other group was treated with saltwater.

The group treated with the Resolvin E1 solution showed minimal atherosclerosis and diminished plaque rupture in their aortic artery. The atherosclerosis in the saline group worsened.

“Current therapies for advanced atherosclerosis are inadequate and often carry high risks, and the Resolvin E1 therapy could provide a very effective and safe therapy that can be taken daily, which would also serve as a preventive approach for plaque inflammation and acute clinical events of heart attack and stroke,” said researcher James A. Hamilton, Ph.D., Boston University School of Medicine.

This research was published in the journal Current Atherosclerosis Reports.

source: BUMC
Photo Credit: Hafiz Issadeen

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