Healing Molecule May Help Treat Diabetes Related Tissue Damage

Researchers are learning more about a molecule in the body that could help treat non-healing injuries or wounds, including diabetic foot.

Diabetic foot is a foot with disease, or damage owed to having diabetes, or a diabetes complication.

The molecule being studied, called deoxyribose-1-phosphate, stimulates the formation of blood vessels, a process that is critical when the body responds to tissue damage. Knowing how deoxyribose-1-phosphate works could lead to new treatment options that facilitate tissue healing.

“We're very excited to provide new insights into how this crucial molecule works to stimulate the formation of blood vessels in people,” said research team leader Dr. Giordano Pula, University of Exeter Medical School. “We now hope to be able to use this knowledge to trigger the formation of new blood vessels in patients where this is required for tissue regeneration, such as diabetic foot.”

The Exeter study showed that deoxyribose-1-phosphate stimulates an enzyme called NADPH oxidase 2 (NOX2). Then, the NOX2 activates NFkB, a transcription factor that turns on genes involved in the creation of new blood vessels.

Among the genes activated for blood vessel formation, a primary role was played by the vascular endothelial growth factor receptor 2 (VEGFR2). Since VEGFR2 is an important target in regenerative research, the investigative team is hopeful this study will precipitate a cost-effective way to facilitate blood vessel formation.

The research team's next step is studying deoxyribose-1-phosphate’s ability to promote skin repair by increasing blood vessel formation in wounds and non-healing ulcers. Ultimately, they hope their work will help treat diabetic foot, and reduce the incidence of diabetes-related amputations.

Source: University of Exeter
Photo credit: kuldeep singh

Get a Free Diabetes Meal Plan

Get a free 7-Day Diabetes Meal Plan from Constance Brown-Riggs who is a Registered Dietitian-Certified Diabetes Educator and who is also a national spokesperson for the American Dietetic Association.

Just enter in your email below to download your free Diabetes Meal Plan.

By clicking Submit, you agree to send your info to InformationAboutDiabetes.com who may contact you with updates and information and we agree to use it according to our privacy policy.

More Articles

Limiting our intake of highly processed foods, and eating more whole and lightly processed fare can boost our nutrient and fiber intake, lower...

Chamomile tea has long been prized for its calming properties, but few people realize it’s also beneficial for glucose regulation. Traditionally,...

Today, the healing benefits of essential oils are more than the claims of ancient tradition and alternative medicine. They are increasingly the...

The different sugar content of fruits can be confusing when you are trying to manage your...

There is nothing close to a one-size-fits-all exercise program for those with diabetic peripheral neuropathy. The best general advice is to...

More Articles

Chamomile tea has long been prized for its calming properties, but few people realize it’s also beneficial for glucose regulation. Traditionally,...

There is nothing close to a one-size-fits-all exercise program for those with diabetic peripheral neuropathy. The best general advice is to...

”Metabolic memory” (less commonly known as ”hyperglycemic memory” or “legacy effect”) refers to the lingering effects of a long period of either...

Limiting our intake of highly processed foods, and eating more whole and lightly processed fare can boost our nutrient and fiber intake, lower...

With such a marked increase in the number of new diabetes cases, more people are wondering if type 1 diabetes...

Do not let pictures of yoga experts with their bodies twisted into bizarre, compact shapes fool you. Even people with stiff muscles, creaky joints...

The American Diabetes Association estimates that more than 7 million people in the United States have diabetes but don’t know it yet. These people...

While some celebrities aren't quick to talk about living with diabetes, others are quite transparent and inspiring - acting as advocates for the...

People with diabetes are about twice as likely to experience heart disease as those without the condition, making cardiovascular health a critical...

All diabetics know that maintaining proper blood sugar levels is the lifeline...

Pilates is an exercise method proven to improve flexibility, strength, coordination, muscular stamina, balance, and posture. Many Pilates...

It can be difficult enough to get on stage and make a roomful of strangers laugh, but for comedians suffering from type 1 or type 2 diabetes,...

Most people with insulin-dependent diabetes use syringes and lancets every day. However, many of them do not know how to dispose of these...

Explaining diabetes to children can seem like a daunting task, but in reality, it is no more difficult than discussing anything else important....

Diabetes is a complex disease, affecting virtually every part of the body. The damage it does, to nerve endings, blood vessels, organs, and the...