New drug treats root cause of type 2 diabetes, could reverse the disease

A modified version of niclosamide, a drug that currently treats intestinal parasites, could be the key to reversing type 2 diabetes, according to new research from a Rutgers professor.

Victor Shengkan Jin reports that one of the major causes of insulin resistance is excessive fat in the liver, which prevents the body from absorbing glucose and using it as fuel.

The new drug, however, burns away this excess fat in a process called mitochondrial uncoupling - which enables the cells to burn away the fat.

“The cell is like a car and the mitochondria are the engine,” Jin said in an article on Rutgers' website. “What we’re doing inside cells is like putting the car’s transmission into neutral by uncoupling it from the transmission. Then you step on the gas so the engine runs full throttle but the car doesn’t move. If too much of the fuel in the cell is fat, you keep burning it until the fuel gauge reaches empty. Without the interference of fat, you hope that sugar will then enter the cell normally.” 

Resetting insulin

Without excessive fat in the liver, cells can appropriately respond to insulin and enable better regulation of blood sugar.

The drug hasn't been tested in humans, but Jin says the results seen in mammals point to the idea that it would have a good safety profile for people too.

"We wanted a safe and practical compound to deplete fat inside cells,” he explained. “We went to the literature and found an approved drug that does in parasitic worms what we wanted to do in liver cells."

The study is published in the journal Nature Medicine.

Source: Rutgers

Get a Free Diabetes Meal Plan

Get a free 7-Day Diabetes Meal Plan from Constance Brown-Riggs who is a Registered Dietitian-Certified Diabetes Educator and who is also a national spokesperson for the American Dietetic Association.

Just enter in your email below to download your free Diabetes Meal Plan.

By clicking Submit, you agree to send your info to InformationAboutDiabetes.com who may contact you with updates and information and we agree to use it according to our privacy policy.

More Articles

It is estimated that 80,000 children and adolescents each year are diagnosed with juvenile diabetes. Juvenile diabetes is diagnosed when the body...

As the summer months come to an end, we throw aside our swimsuits and bring out our favorite team jerseys! In America, fall means football, and...

The medical community relies heavily on the goodwill of its citizens, as giving blood and organ donations help save thousands of lives every year...

Evidence is mounting that consuming black cumin helps to manage type 2 diabetes. The spice lowered blood glucose...

It's not uncommon to spend several years living with type 2 diabetes and not even know you have the condition. Despite regular check-ups with your...

More Articles

Type 2 diabetes has become so common in Western culture and media that this often lifelong, serious condition doesn't really raise an eyebrow...

Limiting our intake of highly processed foods, and eating more whole and lightly processed fare can boost our nutrient and fiber intake, lower...

Lantus is a once a day insulin injection that is taken at the same time every day. It replaces anywhere from the average three to five insulin...

Improving your A1C reading requires you to maintain consistently healthy blood...

Just because you have diabetes doesn't mean you can't help your community by being a blood donor. When persons with diabetes maintain good control...

Most of us do not regularly keep the fruit that scientists call Fortunella margarita in our refrigerator. That these small, yellow-orange...

A diagnosis of diabetes usually comes with a list of recommended lifestyle changes. To make these diet and exercise...

Having diabetes affects your body’s ability to handle hot, humid weather, and steamy temperatures can degrade diabetes supplies. But all of this...

Fashion and function come together in clothing developed by AnnaPS, making life a bit more comfortable and convenient for insulin users. The...

Not only is dry skin uncomfortable, but scratched or cracked skin is also susceptible to bacterial and fungal infections – common medical...

One way to ensure our body gets a variety of nutrients is eating nutrient-dense foods, and one of the most nutrient-dense foods on our planet is...

Financial aid and scholarship money are available for people with diabetes, but acquiring it requires an investment of time and patience. Whether...

Any sweetener you use to replace table sugar is a sugar substitute. One type of sugar substitute is artificial sweetener. Three other types...

Smoking is a proven health hazard for everyone, but it is an especially dangerous habit for those with diabetes. Research shows that smokers with...

While life on the road can be tough on musicians, it’s especially challenging for those battling diabetes. Some musicians have to check their...