New drug treats root cause of type 2 diabetes, could reverse the disease

A modified version of niclosamide, a drug that currently treats intestinal parasites, could be the key to reversing type 2 diabetes, according to new research from a Rutgers professor.

Victor Shengkan Jin reports that one of the major causes of insulin resistance is excessive fat in the liver, which prevents the body from absorbing glucose and using it as fuel.

The new drug, however, burns away this excess fat in a process called mitochondrial uncoupling - which enables the cells to burn away the fat.

“The cell is like a car and the mitochondria are the engine,” Jin said in an article on Rutgers' website. “What we’re doing inside cells is like putting the car’s transmission into neutral by uncoupling it from the transmission. Then you step on the gas so the engine runs full throttle but the car doesn’t move. If too much of the fuel in the cell is fat, you keep burning it until the fuel gauge reaches empty. Without the interference of fat, you hope that sugar will then enter the cell normally.” 

Resetting insulin

Without excessive fat in the liver, cells can appropriately respond to insulin and enable better regulation of blood sugar.

The drug hasn't been tested in humans, but Jin says the results seen in mammals point to the idea that it would have a good safety profile for people too.

"We wanted a safe and practical compound to deplete fat inside cells,” he explained. “We went to the literature and found an approved drug that does in parasitic worms what we wanted to do in liver cells."

The study is published in the journal Nature Medicine.

Source: Rutgers

Get A Free 7 Day Diabetes Meal Plan

Get a free 7-Day Diabetes Meal Plan from Constance Brown-Riggs who is a Registered Dietitian-Certified Diabetes Educator and who is also a national spokesperson for the American Dietetic Association.

Just enter in your email below to download your free Diabetes Meal Plan.

By clicking Submit, you agree to send your info to InformationAboutDiabetes.com who, in addition to 3rd party partners, may contact you with updates, products and information and we agree to use it according to our privacy policy and terms and conditions.

More Articles

Eleven Clinical Studies

After eleven clinical studies and 300,000 participants, researcher Vasanti Malik and her team of researchers...

Diabetic women often have a harder time losing weight than non-diabetic women. A study funded by Jenny Craig proved that diabetic women have an...

Many recent studies have proved that magnesium levels are lower in patients with diabetes than in non-diabetics. This magnesium...

Fluid retention, also known as edema, is a problem that affects many diabetics, especially those with type 2 diabetes...

Some of us might be thrilled if we could manage our blood sugar by sitting in a hot tub or sauna, instead of working up a sweat biking, or using...

More Articles

Cooking and baking with the ancient cereal grain sorghum has health benefits for people with diabetes, and those with weight control issues....

When it comes to certain foods, there are always questions as to whether or not a diabetic can have them without...

With its slightly nutty flavor, chewy texture, and nutritional punch farro is an ancient whole grain worth a place in our pantry.

Farro...

Matcha tea is a rich, creamy, full-bodied beverage with amazing nutritional properties that address several diabetes health concerns.

The...

According to information available through the National Institutes of Health, there’s an estimated 462 million people in the world who are...

Salads are good example of foods that type 2 diabetics can enjoy with relatively low guilt. With the right greens and other elements added, salad...

Remaining gainfully employed is important to many people. Those who live with any form of diabetes may find that some lines of work are more...

Learning that you have diabetes does mean making some lifestyle changes. One of the areas that needs attention is your diet. Most people find that...

One of the more challenging aspects of life as a type 2 diabetic is managing your diet. There’s often the temptation to avoid certain foods...

The green, heavily ridged acorn squash is plentiful in the marketplace this time of year. Though, Acorn squash has a high glycemic index rank of...

A 1300-Calorie diet is a way of eating that limits your daily calorie intake to only 1300 calories a day. This is considered a low calorie diet,...

Maca Root is an editable root vegetable, and is known as Peruvian Ginsing. It is a relative of the radish and turnip family, and is remarkable...

One way to ensure our body gets a variety of nutrients is eating nutrient-dense foods, and one of the most nutrient-dense foods on our planet is...

People who use insulin pumps purposefully break their skin, the body’s main defense against bacteria, to receive continuous doses of life-saving...

Most of us associate peripheral neuropathy with diabetes. What might be a surprise is that there are three other forms of neuropathy that are also...