New drug treats root cause of type 2 diabetes, could reverse the disease

A modified version of niclosamide, a drug that currently treats intestinal parasites, could be the key to reversing type 2 diabetes, according to new research from a Rutgers professor.

Victor Shengkan Jin reports that one of the major causes of insulin resistance is excessive fat in the liver, which prevents the body from absorbing glucose and using it as fuel.

The new drug, however, burns away this excess fat in a process called mitochondrial uncoupling - which enables the cells to burn away the fat.

“The cell is like a car and the mitochondria are the engine,” Jin said in an article on Rutgers' website. “What we’re doing inside cells is like putting the car’s transmission into neutral by uncoupling it from the transmission. Then you step on the gas so the engine runs full throttle but the car doesn’t move. If too much of the fuel in the cell is fat, you keep burning it until the fuel gauge reaches empty. Without the interference of fat, you hope that sugar will then enter the cell normally.” 

Resetting insulin

Without excessive fat in the liver, cells can appropriately respond to insulin and enable better regulation of blood sugar.

The drug hasn't been tested in humans, but Jin says the results seen in mammals point to the idea that it would have a good safety profile for people too.

"We wanted a safe and practical compound to deplete fat inside cells,” he explained. “We went to the literature and found an approved drug that does in parasitic worms what we wanted to do in liver cells."

The study is published in the journal Nature Medicine.

Source: Rutgers

Get Free Diabetic Supplies

For a limited time only, you can reduce diabetic supplies costs by more than 90%. Enrolling just take a few minutes. Fill out the form, speak to a representative and get diabetic supplies delivered to your door at little or no cost. Also, you will get a free Diabetes Meal Plan from a Registered Dietitian-Certified Diabetes Educator.

Enter your information below to see if you qualify.

By clicking Submit, you agree to send your info to InformationAboutDiabetes.com who may contact you with updates and information and we agree to use it according to our privacy policy.

More Articles

Chamomile tea has long been prized for its calming properties, but few people realize it’s also beneficial for glucose regulation. Traditionally,...

Matcha tea is a rich, creamy, full-bodied beverage with amazing nutritional properties that address several diabetes health concerns. The trace...

One way to ensure our body gets a variety of nutrients is eating nutrient-dense foods, and one of the most nutrient-dense foods on our planet is...

It would be interesting to know how many people with diabetes actually use blood glucose control solutions to regularly check the accuracy of...

A mood is an internal state or condition of feeling. It colors everything else we experience, much like colored sunglasses add a tint to...

More Articles

When it comes to certain foods, there are always questions as to whether or not a diabetic can have them without...

Those who have not yet been diagnosed with type 2 diabetes can greatly reduce their susceptibility by doing one key...

Although diabetes is common, many people who have been diagnosed do not completely understand how it develops or whether it is hereditary....

With such a marked increase in the number of new diabetes cases, more people are wondering if type 1 diabetes...

It would be interesting to know how many people with diabetes actually use blood glucose control solutions to regularly check the accuracy of...

Any sweetener you use to replace table sugar is a sugar substitute. One type of sugar substitute is artificial sweetener. Three other types...

One way to ensure our body gets a variety of nutrients is eating nutrient-dense foods, and one of the most nutrient-dense foods on our planet is...

Diabetes is a health condition that disrupts the body’s normal production of insulin. Currently, more than one million Americans are diagnosed...

The HbA1c blood test, more commonly known as the A1C, is both a very useful and a very cool calculation of your average blood glucose levels over...

Chamomile tea has long been prized for its calming properties, but few people realize it’s also beneficial for glucose regulation. Traditionally,...

The different sugar content of fruits can be confusing when you are trying to manage your...

A diabetes meal plan is a guide indicating what types of foods, and how much of them, people should eat at meal and snack time. Following a meal...

For many diabetics, muscle pain is just a normal part of life. Prolonged exposure to high blood sugar levels can cause what's called diabetic...

Everyone from grandmothers to physicians tout oatmeal's wholesome goodness and health benefits. But, is oatmeal good for diabetics? Limited...

Diabetes and hypoglycemia appear as very similar conditions because one of the consequences of diabetes can be hypoglycemia. Both conditions...