New "Smart Insulin" 48-hour Delivery System Developed

New research has found an insulin modification that makes it responsive to glucose. The system, which can control blood sugar for two days in mice with type 1 diabetes, is being developed by teams at North Carolina State University and the University of North Carolina at Chapel Hill.

The system was tried in diabetic mice and worked well. Human trials are now being assembled for the drug.

The "smart" insulin reduced blood sugar levels in mice for 48 hours.

Three groups of mice were used in the trial. All of them were type 1 diabetic, with one group receiving the modified insulin, one receiving standard insulin, and the other a placebo.

The "smart" insulin is made up of modified insulin loaded into red blood cells. The blood cell delivery system helps to regulate the release of the insulin itself. The system keeps the insulin within their blood cells until glucose is detected, giving the insulin a more effective delivery and more efficient use.

The team is now evaluating the long-term biocompatability of the modified insulin system and its delivery in another animal model and plans to move into clincal trials as soon as that is complete. If approved for use by diabetics, the new insulin could vastly improve care.

Source: Diabetes.co.uk

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