Diabetes Drug Rosiglitazone Can Increase Fracture Risk

High doses of rosiglitazone, a drug used to treat diabetes, can increase the risk of bone fractures, according to a new study.

Researchers from the University of North Carolina School of Medicine found that rosiglitazone increases bone fat, which consequently can lead to poorer bone health.

“We were surprised by the massive amount of bone fat caused by rosiglitazone,” said Dr. Maya Styner, first author of the study. “The images were just stunning."

Rosiglitazone affects bone fat by packaging extra glucose - which the drug removes from the blood to treat diabetes - into pockets of fat that are deposited in the bone.

Diabetes and bone health

Diabetes already tends to increase bone fat levels and compromise bone health, but the good news is that exercise seems to substantially reduce the fat deposits caused by rosiglitazone.

"Exercise did decrease the volume of bone fat by about 10 percent, which was similar to the decrease we reported seeing in mice that were not given the drug but were instead fed a high-fat diet," Styner said.

Rosiglitazone, which is sold under the brand name Avandia, once had a bad reputation about a decade ago because of heart-related side effects associated with the drug.

Other drugs that use similar mechanisms as rosiglitazone to lower blood sugar may be close to FDA approval.

“Early reports show that the same bone concerns are popping up with these new drugs,” Styner said. “Doctors and patients need to be aware of this.”

Source: University of North Carolina

Image courtesy of stockdevil/FreeDigitalPhotos.net

More Articles

The different sugar content of fruits can be confusing when you are trying to manage your...

More than 71 million Americans suffer from high levels of low-density lipoprotein (LDL) cholesterol. High LDL cholesterol increases the buildup of...

When we enjoy a dinner with high fat content, such as fettucini, buttery garlic bread, and a rich dessert, we might go to bed with our glucose...

Limiting our intake of highly processed foods, and eating more whole and lightly processed fare can boost our nutrient and fiber intake, lower...

It resembles a turnip, resides in the broccoli family, grows mostly in Peru, is considered an aphrodisiac, and it may improve glucose tolerance....

More Articles

The most convenient places in a fridge to store our stock of insulin may not be the best places. We tend to think our refrigerators maintain a...

Detoxification, or detox, diets are typically short-term diets that promise to rid the body of environmental toxins. Most detox plans begin with a...

It resembles a turnip, resides in the broccoli family, grows mostly in Peru, is considered an aphrodisiac, and it may improve glucose tolerance....

More than 71 million Americans suffer from high levels of low-density lipoprotein (LDL) cholesterol. High LDL cholesterol increases the buildup of...

The four most recommended sites for insulin injections were chosen because they share two qualities: They have a generous fat layer just beneath...

Diabetes and hypoglycemia appear as very similar conditions because one of the consequences of diabetes can be hypoglycemia. Both conditions...

The different sugar content of fruits can be confusing when you are trying to manage your...

A study at the Karolinska Institutet in Sweden shows that type one diabetes can be prevented in mice.

The Study

Using diabetes-...

A mood is an internal state or condition of feeling. It colors everything else we experience, much like colored sunglasses add a tint to...

Prednisone is a corticosteroid, which means that it is used to treat certain conditions in the body that are caused by low steroid production....

When diet, exercise, and metformin are not enough to manage type 2 diabetes, physicians might recommend a non-insulin injection medication to help...

Bilberry tea sounds like the favorite drink at a Hobbit cafe, but the mild sounding bilberry comes with a tall list of powerful health benefits....

Because beets have moderately high sugar content, it’s typically recommended that people watching their glucose levels limit beet consumption....

In the search for a diabetes cure, a study stunned even the experts involved. Scientists at a Toronto medical center published findings that...

Eating LCHF, or a Low Carb High Fat diet, is a bit mind-bending for those of us who have learned to consume low-fat and lean. In many respects, it...