Common Antibiotics Do Not Increase Type 1 Diabetes or Celiac Risks

New research from a multinational study has found no link between the use of common antibiotics and an increase of risk for development of type 1 diabetes or celiac in children with a genetic susceptibility for either. The group's findings were published in JAMA Pediatrics and analyzed 8,495 children in the United States, Finland, Sweden, and Germany who were genetically at risk for type 1 diabetes and an additional 6,558 children who were genetically at risk for celiac.

“I thought we should get to the heart of the matter because you want parents to know whether their children are going to be put at risk when a physician prescribes an antibiotic,” said Eric Triplett, PhD, a professor and chair of the department of microbiology and cell science at the University of Florida Institute of Food and Agricultural Sciences and a member of the UF Diabetes Institute.

The more than 13,000 children in the study were prescribed antibiotics more than 38,000 times before the age of 4.

Amoxicillin for common infections was the most common prescription, with middle-ear infections being the most-diagnosed reason for treatment. Other antibiotics, including derivatives of penicillin and erythromycin, made up the rest of the prescriptions. Of the children, 5.5 percent of those at high risk developed type 1 diabetes before the age of four and 11.6 percent had celiac autoimmunity by the age of four. In neither case was exposure to antibiotics, no matter the frequency, associated with increased risks for either condition.

The research was conducted as part of The Environmental Determinants of Diabetes in the Young (TEDDY) study, a multinational investigation designed to identify whether environmental factors such as prescriptions, infections, diet, etc. are risk factors for type 1 diabetes. This particular study included collaboration from the University of Florida, the University of Turku in Finland, Helmholtz Zentrum Munchen in Germany, Lund University in Sweden, the University of Colorado Denver, the University of South Florida, New York University, August University, and the Pacific Northwest Research Institute.

Source: Floridatrend.com

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