New clues about how gastric bypass surgery cures type 2 diabetes

Diabetics battling obesity often turn to gastric bypass surgery as a way to fast track weight loss goals and improve health.

While the surgery has been shown to be highly successful for type 2 diabetes treatment, researchers have not been able to say exactly why the procedure is so effective.

Role of the small intestine

Now, a team from Boston Children's Hospital has revealed that the small intestine is a major player in how gastric bypass surgery can turn around type 2 diabetes.

After studying the health of rats that had undergone the procedure and analyzing the way the small intestine processed glucose, the researchers found this critical organ learns to reprogram itself to produce GLUT-1 – a protein that is usually not present before gastric bypass surgery.

GLUT-1 typically operates as a "transporter" by removing glucose from the blood and using it in the intestine. After gastric bypass surgery, however, researchers found that GLUT-1 disposes excess glucose instead of using it, leading to healthier blood sugar levels.

"We have seen type 2 diabetes resolve in humans after gastric bypass, but have never known why," said Nicholas Stylopoulos from the hopsital's endocrinology unit. "People have been focusing on hormones, fat and muscle, but we have shown in this study that the answer lies somewhere in the small intestine most of the time."

Implications for treatment

Based on the research, new ways of "mimicking" the small intestine's reprogramming process might lead to diabetic treatments that do not require surgery.

While gastric bypass surgery has been shown to help cure diabetes, the authors note that it is usually not a long-term cure.

Stylopoulos said:

The results of our study are promising because – unlike the brain and other organs – intestines are easily accessible. Furthermore, since cells in the intestine have such a short lifespan, we can easily study and pharmacologically manipulate them to use glucose without long-term problems.

Results of the study are published in the journal Science.

Source: Medical News Today

Get Free Diabetic Supplies

For a limited time only, you can reduce diabetic supplies costs by more than 90%. Enrolling just take a few minutes.
1) Fill out the form
2) Speak to a representative
3) Get diabetic supplies delivered to your door at little or no cost.

Also, you will get a free Diabetes Meal Plan from a Registered Dietitian and Certified Diabetes Educator.

Enter your information below to see if you qualify.

By clicking Submit, you agree to send your info to InformationAboutDiabetes.com and we agree to use it according to our privacy policy.

More Articles

Doctors use regular assessments of their diabetic patients not only to monitor the progress of the disease but also as opportunities to counsel...

Every body needs insulin, an essential hormone produced by the pancreas that regulates blood sugar by converting glucose into energy. Diabetics...

People are not the only beings who suffer from diabetes. Any mammal with a pancreas can develop the disease through a lack of or impaired insulin...

When is diabetes not really diabetes? When it is Diabetes Insipidus. Diabetes Insipidus is a rare disorder not related to diabetes mellitus,...

When news stations feature stories about diabetes, they tend to include a shot of an overweight body, calling attention to the person's excess...

More Articles

The most well-known variations of diabetes are type 1 diabetes and type 2 diabetes....

Those who have not yet been diagnosed with type 2 diabetes can greatly reduce their susceptibility by doing one key...

There are those who have heard of the term "diabetes mellitus," but might not be familiar with it. Diabetes Mellitus is a condition in...

Not only is dry skin uncomfortable, but scratched or cracked skin is also susceptible to bacterial and fungal infections – common medical...

=It’s helpful to know the difference between a food’s total grams of carbohydrate, and net grams of carbohydrate since only net carbs affect blood...

Eating LCHF, or a Low Carb High Fat diet, is a bit mind-bending for those of us who have learned to consume low-fat and lean. In many respects, it...

A 1-minute quiz could predict whether or not you're at risk for prediabetes. More than 1 in 3 adults in the U.S. have prediabetes, which - left...

The human body needs chromium, a trace mineral, for several essential functions including the normalizing of...

Do not let pictures of yoga experts with their bodies twisted into bizarre, compact shapes fool you. Even people with stiff muscles, creaky joints...

It can be difficult enough to get on stage and make a roomful of strangers laugh, but for comedians suffering from type 1 or type 2 diabetes,...

Because beets have moderately high sugar content, it’s typically recommended that people watching their glucose levels limit beet consumption....

It would be interesting to know how many people with diabetes actually use blood glucose control solutions to regularly check the accuracy of...

Gestational diabetes is a condition characterized by abnormally high blood glucose levels during the condition...

How frustrating to wake up in the morning with elevated blood sugar when all you did was dream about eating a piece of cheesecake. A seemingly...

There is nothing close to a one-size-fits-all exercise program for those with diabetic peripheral neuropathy. The best general advice is to...