Link Found Between Biological Clock and Diabetes

Researchers have found a protein that regulates a person’s biological clock that also regulates the production of glucose. It also leads them to believe that it plays an important role in a person developing diabetes and obesity.

What they Have to Say about the Protein Cryptochrome

“We know that mice that don't have good biological clocks tend to develop diabetes and obesity," said Steve Kay, Dean of the Division of Biological Sciences at UC San Diego and one of the lead authors of the research study.” “And we know that mice that have developed diabetes and obesity tend not to have very good biological clocks. This reciprocal relationship between circadian rhythm and the maintenance of a constant supply of glucose in the body had been known for some time. But what we found that's so significant is that a particular biological clock protein, cryptochrome, is actually regulating how the hormone that regulates glucose production in the liver works in a very specific way."

What There Discovery Could Mean for Diabetics

“The scientists discovered is to regulate a process known as “gluconeogenesis,” in which our bodies supply a constant stream of glucose to keep our brain and the rest of our organs and cells functioning. When we're awake and eating, sufficient glucose is supplied to our bloodstream. But when we're asleep or fasting, glucose needs to be synthesized from the glycogen stored in our liver to keep our glucose levels up.”

Diabetics could benefit from regular sleep cycles and eating their meals at the same time each day. This discovery also shows more of how a person could have developed diabetes due to their lifestyle prior to diagnosis.

Source: Steven Kay and Eric Zhang

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