Gene Variations Associated With Risk Of Type 2 Diabetes

According to a study published in the March 2 issue of JAMA. Certain variations of the gene HMGA1 are associated with type 2 diabetes among those of white European descent.

HMGA1

“There is considerable evidence that heredity is a major contributor to the insulin resistance of type 2 diabetes, according to background information in the article. "However, despite extensive investigations, including studies of candidate genes and the recent genome-wide association studies, the common genetic causes of insulin resistance remain elusive," the authors write. The researchers previously found that the protein HMGA1 is a key regulator of insulin receptor (INSR) gene expression.”

Researchers Conclusion

The researchers results indicate that variants in the HMGA1 gene are associated with type 2 DM in individuals of white, European descent. “Further studies of the HMGAl gene and its variants, including studies in other racial types, are needed to understand the role of HMGA1 in insulin resistance and type 2 diabetes."

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