Recent Study Discovers how Blood Vessel Damage in Diabetics Occurs
Researchers at Washington University School of Medicine in St. Louis has discovered how blood vessels in diabetics happens. Although, blood vessel problems are a common complication of diabetes scientists hope to find a way to curtail the damage that can be caused and avoid amputations, strokes, and vision loss.
Researchers and scientists have discovered two enzymes that are linked to the problem during a lab study using mice. Some of the mice had been genetically engineered so that their blood vessels were similar to that of a diabetic animal.
Also called Fastie is the result of the genetic engineered enzymes in the mice. It was discovered that the mice “without FAS, and with low levels of FAS, could not make the substance that anchors nitric oxide synthase to the endothelial cells in blood vessels.”
Without FAS, the genetically engineered mice lose NOS (nitric oxide synthase) and are unable to modify NOS so that it will interact with the endothelial cell membrane. That results in blood vessel problems. The next step is the figure out how to prevent the loss of the nitric oxide synthase in humans to stop the potential blood vessel damage.