Lisofylline - May be One of the Next Type 2 Diabetic Medications
Lisofylline is an anti-inflammatory agent that has completed phase 1 of clinical trials as a new type 2 diabetic medication. Drs Georgia Frangioudakis and Carsten Schmitz-Peiffer who have been working with lab mice believe that lisofylline “works by preventing the build-up of certain by-products of fat metabolism.”
"Fats build up in the muscle and liver cells of obese people or high-fat fed mice. When those fats are metabolized, their breakdown products prevent the normal movement of glucose into cells." Therefore, when a person becomes overweight or obese the glucose is not as effective.
How Lisofylline May be Helpful
The doctors go on to explain how lisofylline may be helpful “Lisofylline is effective in preventing the build up of a number of fat metabolites, including Ceramide. While we don't yet understand all the mechanisms, we believe the blocking of Ceramide may have something to do with the drug's anti-inflammatory properties."
It may be a while before lisofylline is approved by the FDA for the use in treating type 2 diabetes as it just completed phase 1 in laboratory mice. However, the findings look promising and hopefully human clinical trials will prove that lisofylline will be a good diabetic medication.