Cellular Mechanism for Type 2 Diabetes and Chronic Inflammation Discovered
Researchers at Boston University School of Medicine (BUSM) have discovered and been able to demonstrated that certain T cells require input from monocytes in order to maintain their pro-inflammatory response in individuals with type 2 diabetes.
The Lab Study
The study showed, for the first time, how a loss in homeostasis in this group of T cells most likely promotes the chronic inflammation linked to the type of inflammation seen in individuals with type 2 diabetes.
Previous research performed on lab mice has shown that T cells play a vital role in the development of insulin resistance in response to a high fat diet. Additional findings indicate that T cells exhibit a pro-inflammatory response more often than an anti-inflammatory response.
Human Clinical Study
“Working with human T cells, the team observed that in order for T cells to exhibit the pro-inflammatory response, they required constant interaction with monocytes, indicating that monocytes play an indirect role in chronic inflammation and type 2 diabetes.”
If the immune cells could be altered to become balanced then perhaps a treatment for type 2 diabetes anti-inflammatory condition could be better treated as well as correcting the insulin resistance.